Effect of Vitamin D on Glucose Homeostasis, Sensitivity and Insulin Resistance in Type 2 Diabetes

 

Abstract

Background: In recent years, non-bone diseases have been reported with vitamin D deficiency, one of them is type 2 diabetes, which is a group of metabolic disorders caused by insulin action deficiency. Evidences suggest that vitamin D deficiency affects the metabolic function of cells, including beta-pancreatic cells. Regarding the fact that some studies have shown the effect of vitamin D on control of type 2 diabetes, the present study aims to review on the relationship between vitamin D, glucose homeostasis and insulin resistance type 2 diabetes.

Methods: This study is a review on descriptive and analytic studies which accessed data using biochemical tests, questionnaires and interviews. By using key words on vitamin D, type 2 diabetes and insulin resistance, 10 articles including descriptive-analytic, cross-sectional, case-control and interventional types from 1986 to 2018 were conducted.

Results: Many studies have shown that vitamin D levels of 25-hydroxyvitamin D in diabetics, women, and obese people are lower than others. It shows the effect of vitamin D on glucose homeostasis. In addition, vitamin D has an effect on intracellular calcium therefore it influences on insulin secretion. It can be said that vitamin D deficiency causes calcium inefficiency to regulate insulin secretion.

Conclusion: According to studies, it can be concluded that vitamin D might be effective in preventing type 2 diabetes and its controlling. Also, there is no association between vitamin D and insulin secreted by food and hemoglobin A1c (HbA1c). 

 

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