Juniper Publishers-Journal of Diabetes Obesity Journal

  CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL JUNIPER PUBLISHERS Authored by Fadwa M Alsharif Abstract Background & Objective: Sickle cell anemia (SCA) comprises an inherited blood disorder that is lifelong and affects many people globally. Despite progress in therapy, SCA is a considerable cause of mortality and morbidity. This study was designed to measure the immunological parameters and inflammatory cytokines of Saudi patients with sickle cell anemia (SCA) in asymptomatic steady state. Material and Methods: Fifty asymptomatic sickle cell anemia patients and fifty age- and sex-matched healthy non-sickle cell disease subjects were involved in this study. Results: The number of white blood cells, neutrophil, lymphocytes, eosinophils, basophils, CD3, CD4 and CD8 count were significantly elevated in stable-state SCA patients when compared with healthy controls. In addition, the mean value of CRP, TNF-α, IL-2, IL-4, IL-6 and IL...

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF DIABETES & OBESITY JOURNAL Abstract Recently, two strategies are generally applied in clinical practice to treat diabetes, namely, glucagon like peptide-1 (GLP-1) analogs and inhibitors of the enzyme dipeptidylpeptidase-IV (DPP-4) that degrades both GLP-1 and glucose dependent insulin tropic polypeptide (GIP). Physiologically, after food ingestion, enteroendocrine cells in the intestinal mucosa may release the incretins, including GLP-1 and GIP, that can stimulate insulin secretion from endocrine pancreas and thereby decrease blood glucose. GLP-1 is produced and released mainly by L-cells located in the distal ileum while GIP is secreted by enteroendocrine K-cells in the proximal gut. However, GIP is not focused in clinics because diabetic patients are mostly GIP resistant. Therefore, development of agent(s) that may enhance GLP-1 pathway received increasing attentions in recent. Many G protein-coupled recept...