Juniper Publishers-Journal of Diabetes Obesity Journal

CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL JUNIPER PUBLISHERS Authored by Pikee Saxena Abstract Hyperglycemia in pregnancy is associated with adverse fetal and maternal outcomes. Even lower values of glucose intolerance have been shown to be detrimental and adverse effects are proportionate to the plasma glucose levels. However, defining glucose intolerance in pregnancy has been an issue of considerable debate, and has led to different recommendations by various authorities worldwide over the last three decades. Multitude of procedures have been described and glucose cut offs proposed for the diagnosis of glucose intolerance in pregnancy have led to considerable confusion. There are a number of controversies regarding significance of screening for gestational diabetes mellitus (GDM), universal/selective screening, when to screen and how to screen-using single or double step, how much should be the glucose load, how many samples to be taken, fastin...

CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL JUNIPER PUBLISHERS Authored by Amit Kumar Abstract Real World Evidence (RWE) studies generate data that helps fill the knowledge gap between clinical trials and actual clinical practice setting. RWE studies generate data across different age groups, races, ethnicities, varying severities, unstudied co-morbid conditions, differing concomitant drugs (including OTC medications), lifestyle variations and differing adherence/compliance patterns. RWE studies are across very large number of patients and therefore may help unearth rarer ADRs which are not evident in relatively smaller populations in clinical trials. By definition the RWE studies are across larger and more diverse populations than the more controlled setting of Clinical trials which are conducted across a relatively smaller number of subjects. Given that controls are lesser in real world setting of actual practice, it is difficult to enr...