Juniper Publishers-Journal of Diabetes Obesity Journal

CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL JUNIPER PUBLISHERS Authored by Rosario Scaglione Abstract Objective: The principal objective of this study was to demonstrate the role of obesity and adiponectin (ADPN) in the occurrence of Left ventricular hypertrophy (LVH) in subjects with Metabolic Syndrome (MetS). The study population consisted of 79 patients affected by MetS, according to NCEP/ATPIII criteria, and 126 without MetS, utilized as controls. BMI, waist to hip ratio (WHR), mean blood pressure (MBP), ADPN levels and HOMA index were measured. Left ventricular internal diameter (LVID/h), interventricualr septal thickness (IVST), indexed LVM (LVMI), relative wall thickness (RWT), LV ejection fraction by echocardiography and diastolic parameters were calculated. BMI (p<0.003), WHR (p<0.02), MBP (p<0.03) LVM, LVMI and IVST (p<0.001) were significantly higher and ADPN (p<0.001) was significantly lower in subjects...

CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL JUNIPER PUBLISHERS  Authored by Vinay Kumar Abstract Liraglutide is a glucagon like peptide-1 (GLP-1) analogue. GLP-1 is a potent inhibitor of motility and gastric emptying and has also been shown to inhibit gastric acid secretion. The inhibition of gastric emptying leads to decreased food intake and reduced body weight. The aim of the present study was to investigate the antiobesity effect of the Liraglutide on high fat diet (HFD) induced obesity in Wistar rats. Obesity was induced by oral feeding of HFD for six weeks. The antiobesity effect of Liraglutide (0.2mg/kg, i.p. for 14 days) in HFD fed rats was evaluated by the measurement of body mass index (BMI), body weight gain, food intake, hemodynamic changes (systolic, diastolic, mean blood pressure and heart rate), serum leptin, lipid profiles (triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol), glucose. Organ (Liver) and vis...