Juniper Publishers-Journal of Diabetes Obesity Journal

    CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL   JUNIPER PUBLISHERS   Authored by HP Gajera Introduction Background Diabetes mellitus is a carbohydrate metabolism disorder of endocrine system due to an absolute or relative deficiency of insulin secretion, action, or both [1]. The disorder affects more than 100 million people worldwide and it is predicted to reach 366 million by 2030. The non-insulin dependent diabetes mellitus (NIDDM, type 2) is the most prevalent form globally which is associated with elevated postprandial hyperglycemia. The occurrence of NIDDM 2 has been shown an alarming increase during the last decade (http//www.who.Int/diabetes/en/). Plant derivatives with reported hypoglycaemic properties have been used in folk medicine and traditional healing systems. Very few of these traditional antidiabetic plants have received proper scientific or medical scrutiny despite recommendations by WHO. Ayurveda and other Indian traditional approaches have...

  CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL   JUNIPER PUBLISHERS Authored by Ghulam Abbas Abstract Glucagon receptor plays an important role in the glucose homeostasis and thus is drug target for the management of hyperglycemia in type-2 diabetes mellitus. The suppression of glucagon secretion from the alpha-cells is the key to control hyperglycemic condition. The identification of non-peptide antagonists of glucagon receptor is an effective therapeutic approach to inhibit the glucagon secretion to achieve normal glucose index. Keywords:  Glucagon receptor; Hyperglycemia; Diabetes mellitus; Antagonists Go to Introduction Background Diabetes mellitus is a chronic metabolic disorder which is spreading at an alarming rate all over the world. Glucagon receptor belongs to the G protein-coupled receptors (GPCRs) superfamily and an important drug target for type-2 diabetes [1]. G-Proteins (guanine nucleotide binding proteins) actually act as molecular switches to turn o...

    CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL   JUNIPER PUBLISHERS Authored by Essam H Jiffri Abstract Background: Obesity is frequently characterized by chronic systemic inflammation and insulin resistance (IR). Obesity-associated low grade systemic inflammation is responsible for the complement system activation of which the third component (C3) plays the central role. Objective: This study aimed to detect the association between complement system, inflammatory cytokines and glucose control in obese subjects. Methods: Seventy-nine volunteers obese subjects were interviewed, only 68 of them met eligibility criteria, signed the consent form to participate in this study. Their age ranged from 26-43 years and their body mass index (BMI) ranged from 30 to 37kg/m2. In the other hand sixty lean subjects (BMI ≤25 kg/m2) were participated in the study as a control group, the mean age was 36.18±5.84 year and body mass index (BMI) was ≤25kg/m2. All participants who were a...

  CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL JUNIPER PUBLISHERS Authored by Leonid Barski Abstract Management of patients with DKA involves rehydration, administration of insulin, correction of electrolyte derangements, correction of metabolic acidosis, and treatment of precipitant factors. To date there are no randomized prospective studies that have evaluated the optimal hospital site for the management of patients with DKA. The decision where to care for patients with DKA must be based on known clinical prognostic indicators and on the local availability of hospital resources. The response to initial therapy in the emergency department can be used as a guideline for choosing the most appropriate hospital site for further care. The current mainstay of insulin therapy in DKA is continuous intravenous infusion. Recent studies have demonstrated the therapeutic feasibility and cost-effectiveness of the treatment of mild uncomplicated DKA with subcutaneous insulin analogs out...