Juniper Publishers-Journal of Diabetes Obesity Journal

      CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL   JUNIPER PUBLISHERS Authored by Megan N Hodges Abstract Objective: To compare the safety and efficacy of neutral protamine Hagedorn (NPH) insulin to other antidiabetic regimens in the treatment of corticosteroid-induced hyperglycemia in non-critically ill; hospitalized patients. Methods: This retrospective cohort included patients treated with methylprednisolone or prednisone concomitantly with NPH or other antidiabetic medications for at least two days. Patients were screened for inclusion in reverse chronological order and matched based on gender; age; body mass index; steroid dose; and history of diabetes. The primary objective was mean daily blood glucose (BG). Secondary outcomes included percentage of readings between 70mg/dL-180mg/dL; median daily BG; number of hypoglycemic events; daily steroid to NPH ratios; and mean weight-based dose of NPH for each 10mg increment of prednisone when BG readings were w...

Abstract Central obesity poses more threat to human health than general obesity and stress increases its presentation. This study assessed prevalence of central obesity and stress, and their association with hypertension. Two hundred and eighty-three health workers in Jos Teaching Hospital, Plateau State, Nigeria were randomly selected. Socio-demographic characteristics and lifestyles (physical activity, alcohol intake, smoking and stress) were evaluated by semi-structured and International Stress Management Association Questionnaire. Central obesity was determined by waist circumference. Crude overweight, obesity and blood pressure were assessed by Body Mass Index, Body fat percentage and digital sphygmomanometer respectively. Hypertension was defined as BP =140/90mmHg. Descriptive and inferential statistics were performed and significance was set at p<0.05. Study participants were 32% males and 68% females. Mean age was 37±9.5years. Clinical and non-clinical workers wer...

  CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL JUNIPER PUBLISHERS     Authored by Kanwaljit Chopra   Abstract Insulin resistance (IR) is an important link between obesity and post obesity complications varying from diabetes mellitus to neurological insults such as cognitive dysfunction and Alzheimer's disease. Currently available high calorific diet induced preclinical models mimic clinical pathologies of various metabolic disorders but they are highly time consuming. Zymosan a well-known inflammagen has recently been used to induce reversible IR conditions in rodent models. Though, the insulin resistance lasts as long as zymosan is injected to animals, but the pathogenesis that resembles to that of obesity, IR and metabolic syndrome. However, high fat or high carbohydrate diet could be used in combination with zymosan to develop a novel animal model of IR where both inducers act synergistically to exert their primary actions. The comb...