Diabetes Mellitus: could the Inhibition of a Single Enzyme (CPT-1) Involved in the Beta-Oxidation Process Improve this Complex Disease?-Current Research in Diabetes & Obesity Journal-Juniper Publishers


 JUNIPER PUBLISHERS-CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL


DIABETES MELLITUS: COULD THE INHIBITION OF A SINGLE ENZYME (CPT-1) INVOLVED IN THE BETA-OXIDATION PROCESS IMPROVE THIS COMPLEX DISEASE?  

Authored by Piero Chiodi

Diabetes mellitus is a heterogeneous chronic disease characterized by hyperglycemia, and insulin resistance. The causes lie the interaction of genetic and environmental factors that occur with deficiency in production of insulin by the pancreas, or by ineffectiveness of insulin produced.
Diabetes mellitus is among ten leading cause of death in high-income countries and it is increasing rapidly in countries undergoing industrialization. Diabetes alone claims on the average around 8% of total health budgets in developed countries [1]. Complications include diabetic retinopathy, renal failure, heart disease, diabetic neuropathy and foot ulceration and amputation. More than 90% of diabetic patients in the United States are Type 2 diabetics, or non-insulin-dependent diabetes mellitus (NIDDM). In NIDDM a severe glycemic control should be made by a synergic work of physical activity, diabetic diet, and the use of hypoglycemic agents, and lastly insulin.


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