Juniper Publishers-Journal of Diabetes Obesity Journal

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CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL JUNIPER PUBLISHERS Authored by Bernhard Otto Boehm Abstract Patients with type 2 diabetes mellitus (T2DM) suffer from impaired glucose metabolism which results in low-grade inflammation and activation of the innate immune system. Neutrophils the key effector cells of the innate immune system and heavily implicated in the pathogenesis of T2DM, are promising cell-based inflammatory biomarkers for immune health profiling, provided that they can be rapidly purified and measured with sufficient precision. In this review, we highlight recent advances in neutrophil isolation and functional assay using microfluidics technologies and the potential of their functional phenotype as a novel biomarker of vascular risk in diabetes. Keywords: Neutrophils; Diabetes; Point-of-care; Microfluidics; Immunology Introduction With the increasing aging population worldwide, metabolic disor...

CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL JUNIPER PUBLISHERS Authored by  Bangyan L Stiles Introduction Type II Diabetes (T2D) is a complex disease that is influenced by environmental factors such as diet and life style as well as genetic variations that result in deviations in gene expression. Recent genome-wide association studies (GWAS) have established the correlation of more than 70 genetic variants (Single nucleotide polymorphisms or SNPs) with susceptibility to T2D [ 1 , 2 ]. Using highly efficient RNA sequencing (RNA-Seq) approach, it is now possible to comprehensively profile the transcriptome of the islets of Langerhans or individualβcells to better understand how these environmental factors and SNPs contribute to the pathogenesis of type II Diabetes. Next generation sequencing (NGS) technology has revolutionized the field of transcriptomics. RNA-seq is the current gold standard which has overcome the short comings of microarray...