Therapeutic Potential of Gut Microbiome Manipulation: Concepts in Fecal Microbiota Transplantation
Abstract Microbial Alterations and Dysbiosis: The composition and diversity of gut microbiota is an indicator of health and various groups of commensal bacteria provide health advantages as they enhance metabolism, the immune system, cancer resistance, endocrine signaling and brain function. In general, the gut microbiome remains relatively resilient over time, however, antibiotic use, erratic diet, illness and other factors can lead to alterations and dysbiosis, which weaken various elements of the barrier, causing collapse of the mucus layer that separates epithelial cells and microbiota and reduced expression of antimicrobial peptides which control bacteria including C. difficile . FMT- Invasive Gut Microbial Manipulation: FMT is administration of a form of fecal material from the donor into the intestinal tract of the recipient in order to directly modify the recipient’s gut microbial composition suitably to confer health benefits. FMT has been used to success