Juniper Publishers-Journal of Diabetes Obesity Journal

CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL JUNIPER PUBLISHERS Authored by Fan Fan   Abstract Alzheimer’s disease (AD) is the leading cause of progressive degenerative dementia. The hallmark pathological features include beta amyloid deposition and neurofibrillary tangles. There has been astrong association of AD with Diabetes (DM) based on human studies and animal experiments. The hallmark features of AD seem to have an exaggerated presence in AD with DM, especially type 2 diabetes (T2D). In addition, insulin resistance is a common feature in both diseases and as such AD has been called type 3 diabetes. Furthermore, impairment of cerebral autoregulation has been reported in both animal and human diabetic subjects. Cerebral vascular impairment has also been implicated in the pathophysiology of AD. There is an urgent need to develop animal models of AD and DM to explore the neuropathological mechanisms of these disease and utilize such mod

CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL JUNIPER PUBLISHERS Authored by Vismay Naik  Introduction Cushing's syndrome (CS) is defined as an outcome of prolonged exposure to glucocorticoids whether from outside or inside sources. It's a relatively rare condition with an incidence of 0.7-2.4 per million population per year [1]. Clinical presentation in primary care setting can be highly variable, and establishing the diagnosis can often be difficult and is frequently missed due to its rarity and overlapping characteristics with common disorders like metabolic syndrome. Early diagnosis and treatment of CS is associated with a decrease in morbidity and mortality [2]. The objective of this article is to discuss the most appropriate screening test that could be performed in primary care in clinically suspected cases of CS. Etiology of Cushing’s Syndrome Exogenous administration of glucocorticoids (Iatrogenic