Juniper Publishers-Journal of Diabetes Obesity Journal

CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL   JUNIPER PUBLISHERS   Authored by Evasio Pasini Abstract Exercise plays a significant role in the prevention of the diabetes. Recent data propose that dysbiosis of intestinal microbiota composition contributes to development of Type 2 diabetes (T2D). Moreover, dysbiosis alters intestinal endothelium permeability causing the “ Leaky gut syndrome ” (LGS). We measured in 15 selected patients with standard medical cures for sable T2D the effects of 6 months of endurance, resistance and flexibility training on the gut microbiota composition and intestinal permeability. At baseline, T2D patients had high biochemical parameters (glycaemia, HOMA index, HbA1c, C-Reactive Protein [CRP]) with dysbiosis (elevated concentration of Mycetes) and altered intestinal impermeability (Measured by faecal Zonulin). Alter chronic exercise, glycaemia, HOMA index, HbA1c and CPR were reduced as well as faecal presence of Mycetesspp and Zonulin. This p...

 

  CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL   JUNIPER PUBLISHERS   Authored by H B Chandalia   Abstract There is a rapidly increasing epidemic of type 2 diabetes in India and other Asian countries due to rapid urbanization and lifestyle changes occurring in the country. India faces several challenges in diabetes management, including a rising prevalence in urban and rural areas, lack of disease awareness among the public, limited health care facilities, high cost of treatment, and rising prevalence of diabetic complications. Current antidiabetic agents fail to address disease progression and are often associated with weight gain and risk of hypoglycemia. SGLT2 represents a novel target for the treatment of diabetes. The mechanism of SGLT2 inhibition is independent of circulating insulin levels or insulin sensitivity; therefore, these agents can be combined in type 2 diabetes with all other antidiabetic classes, including exogenous insulin. Dapagliflozin is t...

    CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL   JUNIPER PUBLISHERS Authored by Zeinab Jannoo Introduction Health-Related Quality of Life (HRQoL) assesses the impact of illnesses on the physical, mental and social well-being of individuals and its importance is increasingly recognized [1]. Some instruments are intended for general use, irrespective of illness and the condition of the patient. The generic instruments may often be applicable to healthy people too. Some of the earliest ones were developed initially with population surveys in mind, but later was extended to include clinical trial settings. These instruments are commonly described as Quality of Life (QoL) scales and they are measures of health status since the focus is mainly on physical symptoms. Whilst the generic QoL instruments measure QoL generally and assess the various health domains, the diabetes-specific QoL is more sensitive to changes and is specific to the disease per se [2]. There are many...