Juniper Publishers-Journal of Diabetes Obesity Journal

    CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL   JUNIPER PUBLISHERS Authored by Essam H Jiffri Abstract Background: Obesity is frequently characterized by chronic systemic inflammation and insulin resistance (IR). Obesity-associated low grade systemic inflammation is responsible for the complement system activation of which the third component (C3) plays the central role. Objective: This study aimed to detect the association between complement system, inflammatory cytokines and glucose control in obese subjects. Methods: Seventy-nine volunteers obese subjects were interviewed, only 68 of them met eligibility criteria, signed the consent form to participate in this study. Their age ranged from 26-43 years and their body mass index (BMI) ranged from 30 to 37kg/m2. In the other hand sixty lean subjects (BMI ≤25 kg/m2) were participated in the study as a control group, the mean age was 36.18±5.84 year and body mass index (BMI) was ≤25kg/m2. All participants who were assigned into t

  CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL JUNIPER PUBLISHERS Authored by Leonid Barski Abstract Management of patients with DKA involves rehydration, administration of insulin, correction of electrolyte derangements, correction of metabolic acidosis, and treatment of precipitant factors. To date there are no randomized prospective studies that have evaluated the optimal hospital site for the management of patients with DKA. The decision where to care for patients with DKA must be based on known clinical prognostic indicators and on the local availability of hospital resources. The response to initial therapy in the emergency department can be used as a guideline for choosing the most appropriate hospital site for further care. The current mainstay of insulin therapy in DKA is continuous intravenous infusion. Recent studies have demonstrated the therapeutic feasibility and cost-effectiveness of the treatment of mild uncomplicated DKA with subcutaneous insulin analogs outside

  CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL   JUNIPER PUBLISHERS Authored by Peter Buchwald Abstract Metabolism of the amino acid L-arginine is implicated in many physiological and pathophysiological processes including autoimmune conditions such as type 1 diabetes (T1D). Alternate arginine metabolism through the citrulline-nitric oxide (NO) or the ornithine pathways can lead to proinflammatory or immune regulatory effects, respectively. In this report, we blocked the arginine-ornithine metabolic pathway by inhibiting the enzyme arginase-1 with Nω-hydroxy-nor-arginine (nor-NOHA) to make arginine more available to the alternate citrulline pathway for augmented NO production and increased incidence of autoimmune T1D in female non-obese diabetic (NOD) mice. Unexpectedly, mice receiving nor-NOHA did not develop diabetes although increased NO production is proinflammatory and expected to increase diabetes incidence. These results warrant further studies of the mechanism of action o