Naturceuticals: A New Hope for Treatment of Diabetic Complications-Juniper Publishers
CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL JUNIPER PUBLISHERS Authored by Farid A Badria Introduction Diabetes mellitus is collection of metabolic disorders characterized by high serum glucose level in the body that is due to low insulin secretion or due to cellular unresponsiveness toward produced insulin. This high level of glucose produces the conventional symptoms of polyphagia, polydipsiaand polyuria [ 1 ]. Uncontrolled diabetes can cause diverse complications, diabetic ketoacidosis and non ketotic hyperosmolar coma fall under acute complications [ 2 ] while chronic complications comprise multiple tissue damage that results in stroke, cardiovascular disease, foot ulcers, renal failure and eye damage [ 3 ]. The general features of hyperglycemia-induced tissue damage are shown schematically. The DCCT (Diabetes Control and Complications Trial) and the UKPDS (U.K. Prospective Diabetes Study) established that hyperglycemia (far left of the figure) cause